Check out Nonprofit Quarterly's take on how nonprofits are helping in the aftermath of the act of terror and hate in Orlando in the article Orlando’s Angel Wings Project Pits the Spirit of Nonprofit Sector Against Hate. I believe they are right that nonprofits always can be counted upon to step up when tragedy strikes. What nonprofits must get better at, however, is accounting for funds and spending after large sums of money are raised in response to disaster. (For example, American Red Cross is currently having to prove sound spending to the Senate with regards to funds raised after the earthquake in Haiti in 2010). It can be even more difficult when a relatively small nonprofit experiences a great influx of funds - especially if it amounts to more money than is required to help the victims.
A significant amount of the fundraising to help the victim's families in Orlando is running through Equality Florida via a GoFundMe account and the Central Florida Foundation through special funds created for this purpose. Both of these groups should be well positioned to deal with the influx and account for spending. That is a positive thing!
Where donors must be careful is in giving to funding accounts that are set up through various individuals. The intentions are almost always good, but the follow through can sometimes be difficult for someone who doesn't have direct access or connections to the victims. So if you are inclined to give to help the victims and their families in Orlando, please just take a few minutes to vet the charity or fund through which you are donating your money.